Resumo A criação de bezerras está entre as atividades mais importantes da pecuária leiteira, pois reflete a genética e a produção do rebanho. Um bom manejo nutricional de novilhas durante a fase recria é essencial para o desenvolvimento ponderal adequado, pois melhora da função imunológica e precocidade reprodutiva. Este estudo teve como objetivo avaliar a relação do peso de novilhas holandesas com a idade na primeira inseminação artificial, primeiro parto e volume de leite produzido na primeira lactação. Foram utilizados os (...) registros de 200 novilhas holandesas submetidas a inseminação artificial em tempo fixo (IATF) em uma fazenda leiteira na região de Lagoa Formosa, MG, no período de janeiro a dezembro de 2020 a 2023, considerando informações sobre de ganho de peso no período de recria até o primeiro serviço idade na IATF e idade ao primeiro parto, produção de leite (em litros) e tempo de lactação. Os registros com as informações foram tabelados no software Exel® e avaliados. As novilhas foram divididas em três (3) grupos de acordo com o ganho de peso alcançado até a primeira inseminação, sendo: grupo A (GA) acima de 390 kg, grupo B (GB) de 360 a 389 kg e grupo C (GC) abaixo de 359 kg. O GA apresentou menor idade na primeira inseminação e no primeiro parto e maior produção de leite, porém a duração da lactação foi menor em relação aos demais grupos. O escore corporal se mostrou determinante para o bom desempenho na reprodução, na produção e na geração de renda ao produtor. -/- Abstract Raising calves is among the most important activities in dairy farming, as it reflects the genetics and production of the herd. Good nutritional management of heifers during the rearing phase is essential for adequate weight development, as it improves immune function and reproductive precocity. This study aimed to evaluate the relationship between the weight of Holstein heifers and age at first artificial insemination, first calving and volume of milk produced in the first lactation. We used the records of 200 Holstein heifers submitted to fixed-time artificial insemination (FTAI) on a dairy farm in the region of Lagoa Formosa, MG, from January to December 2020 to 2023, considering information on weight gain in the period from rearing to first service age at TAI and age at first calving, milk production (in liters) and lactation time. The records with the information were tabulated in the Exel® software and evaluated. The heifers were divided into three (3) groups according to the weight gain achieved until the first insemination, being: group A (GA) above 390 kg, group B (GB) from 360 to 389 kg and group C (GC) below 359 kg. The GA showed a younger age at first insemination and first birth and higher milk production, but the duration of lactation was shorter compared to the other groups. Body score proved to be decisive for good performance in reproduction, production and income generation for the producer. -/- Resumen La cría de terneros es una de las actividades más importantes en la ganadería lechera, ya que refleja la genética y la producción del rebaño. Un buen manejo nutricional de las novillas durante la fase de cría es esencial para un adecuado desarrollo del peso, ya que mejora la función inmune y la precocidad reproductiva. Este estudio tuvo como objetivo evaluar la relación entre el peso de las vaquillonas Holstein y la edad a la primera inseminación artificial, primer parto y el volumen de leche producida en la primera lactancia. Se utilizaron los registros de 200 novillas Holstein sometidas a inseminación artificial en tiempo fijo (FTAI) en una granja lechera de la región de Lagoa Formosa, MG, de enero a diciembre de 2020 a 2023, considerando información sobre ganancia de peso en el período de recría a primera edad de servicio en TAI y edad al primer parto, producción de leche (en litros) y tiempo de lactancia. Los registros con la información fueron tabulados en el software Exel® y evaluados. Las vaquillonas se dividieron en tres (3) grupos de acuerdo a la ganancia de peso lograda hasta la primera inseminación, siendo: grupo A (GA) por encima de 390 kg, grupo B (GB) de 360 a 389 kg y grupo C (GC) por debajo de 359 kg. El AG mostró una menor edad a la primera inseminación y al primer parto y mayor producción de leche, pero la duración de la lactancia fue menor en comparación con los otros grupos. La puntuación corporal resultó ser determinante para un buen desempeño en la reproducción, la producción y la generación de ingresos para el productor. (shrink)

RESUMO A Transferência de Embrião (TE) em bovinos se trata de uma técnica mundialmente disseminada com objetivo de aumentar a capacidade reprodutiva da fêmea. Mantém vínculo direto com outras técnicas das biotecnologias da reprodução, como, a Ovum Pick-Up (OPU), Produção In Vitro e In Vivo de embriões (PIVE) e Transferência de Embrião em Tempo Fixo (TETF), sendo estas, técnicas que fazem parte de um processo, que vai desde a seleção de doadoras, passando pelo preparo dos embriões até sua inovulação em (...) receptoras criteriosamente selecionadas. Com seu avanço, várias tecnologias de manejo vêm sendo implantadas: formas no transporte de embriões, protocolos de sincronização de doadoras e receptoras, e protocolos de recuperação de oócitos para produção de embriões. Isto infundiu a tecnologia, porém, os investimentos previstos para a produção de um animal de alto mérito genético limita sua utilização. Contudo, esta análise abordou avanços tecnológicos essenciais para o sucesso da TE, incluindo novos protocolos, sexagem de embriões, além do uso de embriões congelados Direct Transfer (DT) e vitrificados. No entanto, é claro que o sucesso do procedimento está no processo como um todo, em destaque ressalta-se que é de grande valia que o profissional apto a executar a técnica esteja sempre preparado e atualizado garantindo qualidade, eficiência e sustentabilidade na pecuária. Esta revisão foi desenvolvida com o propósito de adquirir conhecimento teórico, de forma detalhada e crítica, nas técnicas e procedimentos de Transferência de Embriões em bovinos, incluindo a colheita, manipulação e implantação de embriões. Palavras-chaves: Bovino, doadora, embrião, receptora. ABSTRACT Embryo Transfer (ET) in cattle is a globally widespread technique aimed at enhancing the reproductive capacity of females. It is closely linked to other techniques in reproductive biotechnologies, such as Ovum Pick-Up (OPU), In Vitro and In Vivo Embryo Production (PIVE), and Timed Embryo Transfer (TET), all of which are part of a process that ranges from donor selection, through embryo preparation, to their inoculation into carefully chosen recipients. With its advancement, various management technologies have been implemented: including methods for embryo transport, synchronization protocols for donors and recipients, and oocyte recovery protocols for embryo production. Although technology has been infused, the anticipated investments for producing animals of high genetic merit limit its widespread use. However, this analysis addressed essential technological advances for the success of ET, including new protocols, embryo sexing, as well as the use of frozen-thawed (DT) and vitrified embryos. Nevertheless, it is clear that the success of the procedure lies in the entire process. Notably, it emphasizes the significant value of having a qualified professional who is always prepared and updated to ensure quality, efficiency, and sustainability in livestock farming. This literary review was developed with the purpose of acquiring theoretical knowledge, in a detailed and critical way, on the techniques and procedures of Embryo Transfer in cattle, including the collection, manipulation and implantation of embryos. Keywords: Bovine, donor, embryo, recipient. -/- REFERÊNCIAS BIBLIOGRÁFICAS BARUSELLI, P.S; MADUREIRA, E.H. Controle farmacológico do ciclo estral em ruminantes. 2000, Anais.. São Paulo: Fundação da Faculdade de Medicina Veterinária e Zootecnia, USP, 2000. BARUSSELI, P.S. et al. Importância do emprego da eCG em protocolos de sincronização para IA, TE e SOV em tempo fixo. Biotecnologia de reprodução em bovinos (3° Simpósio Internacional de Reprodução Animal Aplicada). 2008. BRANDÃO, G.V.R. Revisão de Literatura: Transferência de Embrião em Bovinos. Curitibanos-SC, 2019. BUENO, A.P.; BELTRAN, M.P.; Produção in vitro de embriões bovinos. Revista Científica Eletrônica De Medicina Veterinária. ISSN 1679-7353, ano VI, n.11, Julho, 2008. CAETANO, S.G; SILVA, N.V.S. Inseminação artificial de bovnos em tempo fixo (IATF) – Revisão de literatura. UNIFUCAMP, Monte Carmelo- M.G, Junho, 2023. CARVALHO, V.H.S. et al. Impactos das biotécnicas da reprodução animal e o melhoramento genético na pecuária de corte. PUBVET, São Luis De Montes Belos, v.17, n.8, p.1-10, 2023 DANTAS, K.S.A.; NUNES, C. C. C.; FERREIRA, J.; DANTAS, R. A. A. Seleção de receptoras em um programa de transferência de embriões (PIVE) em bovinos no Nordeste do Brasil. Ciência Animal, Fortaleza, v. 28, p. 1-14, 2018. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia Clínica do Ciclo Estral de Vacas Leiteiras: Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro. 2020. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia do ciclo estral dos animais domésticos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Transferência de Embriões nos Animais e a Indústria de Embriões no Brasil. DIAS, L.R.O. Fatores que afetam a produção de embriões pela Transferência Intrafolicular de Ovócitos Imaturos (TIFOI) em bovinos. 2021. 85 f. Tese (Doutorado em [nome do programa]) - Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, 2021. DOMINGUES, P.F.; LANGONI, H. Manejo Sanitário Animal. Editora de Publicações Biomédicas Ltda - EPUB, Rio de Janeiro, 2001. 209 p. EMBRAPA. MINERAIS NA EFICIÊNCIA REPRODUTIVA DE BOVINOS. SÃO CARLOS- SÃO PAULO 2008. FIDELIS, C.A.S. Inseminação artificial em tempo fixo intracornual profunda em bovinos. Dissertação (mestrado acadêmico). Araguaína - TO, 2019. GONÇALVES, R.L.R.; VIANA, J.H.M. Situação atual da produção de embriões bovinos no Brasil e no mundo. In: Anais do XXIII Congresso Brasileiro de Reprodução Animal, 2019, Gramado, RS, 2019, p. 156-159. GOUVEIA, F.F. A Produção in vitro de embriões Bovinos. Monografia (Conclusão do curso de Medicina Veterinária) – Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF, 2011. GREGIANINI, J.T.F. et al. Avaliação de embriões bovinos utilizando sêmen sexado e convencional. In: SEMINÁRIO DA EMBRAPA ACRE DE INICIAÇÃO CIENTÍFICA E PÓS-GRADUAÇÃO, 4., 2021, Rio Branco, AC. Atividades agropecuárias e florestais para o desenvolvimento sustentável da Amazônia: Anais... Rio Branco, AC: Embrapa Acre, 2022. Pôster. GUARDA, A.C.A. Biotecnologia na reprodução animal: Uma visão teórico/prática de produção in vitro de embriões bovino. 2023. 28p. Trabalho de Conclusão de curso (Bacharelado de Zootecnia). Instituto Federal de Educação, Ciência e Tecnologia Goiano – Câmpus Rio Verde, Rio Verde, GO, 2023. HAFEZ, E.S.E.; HAFEZ. Reprodução animal / [coordenador de tradução da 7. ed. original Renato Campanarut Barnabe]. – Barueri, SP : Manole, 2004, il.; HONORATO, M.T. et al. Importância da escolha de receptoras em um programa de transferência de embriões em bovinos. PUBVET, Londrina, V. 7, N. 19, Ed. 242, Art. 1601, Outubro, 2013. HOPPER, R.M. Bovine Reproduction. Wiley Blackwell, Capítulo 78, p. 723-733, 2015. LIMA, Fabio Junior Arruda. Transferência de embriãos em tempo fixo em bovinos: Relato de Caso. Trabalho de Conclusão de Curso (graduação em medicina veterinária)- Universidade Federal de Santa Catarina-Campus Curitibanos. Curitibanos, 2018. MACHADO, R. et al. Metodologia para obtenção de concepto bovino. Embrapa Pecuária Sudeste, ISSN 1981-2078, São Carlos-SP, 2009. Disponível em:. Acessado em 11 de outubro, 2023 BASTOS, M.R. et al. Criopreservação de embriões bovinos produzidos in vitro. In: MENDONÇA, P. P. et al. (Org.). Tópicos Especiais em Ciência Animal XI. 1. ed. Alegre: CAUFES, 2022. Capítulo 13. MELO, R. et al. Utilização de ECG e FSH em protocolos de superovulação em bovinos. Manejo, Nutrição e Produção Animal: Tópicos Atuais em Pesquisa, v. 1, n. 1, p. 110-116, 2023. OLIVEIRA, C.S. et al. Biotécnicas da Reprodução em Bovinos. EMBRAPA, 2014. PASA, C. Transferência de embriões em bovinos. Biodiversidade, v. 7, n. 1, 2008. PAZZIM, L.V.L. Transferencia de embriões em bovinos: Revisão de literatura. Monografia (Trabalho conclusão de curso) - Universidade federal de Santa Catarina. Curitibanos, 2021. PENITENTE FILHO, J.M. et al. Produção de embriões bovinos in vivo e in vitro. Revista CFMV, Ano XX, p. 73-82, 2014. PENITENTE FILHO, J.M. Produção de Embriões Bovinos In Vivo e In Vitro. 2011. 22 f. Monografia (Especialização) - Curso de Medicina Veterinária, UFV, Viçosa, 2011. PILLA, L.F.C. Congelamento ultra-rapido de embriões bovinos com etilenoglicol associado ou não a trealose. 2005. 37f. Dissertação (Mestrado em Area de concentração em Fisiopatologia da Reprodução), Universidade Federal de Santa Maria, Santa Maria. RIBEIRO, L.V.P.; RIGOLON, L.P.; CAVALIERI, F.L.B.; SEKO, M.B.; MARTINEZ, A.C.; RIBEIRO, M.G.; MARTINS, R.R.; ÁVILA, M.R.; DE CONTI, J.B. Recuperação de oócitos e recuperação in vitro de embriões de vacas estimuladas com FSH ou eCG. Archivos de zootecnia. v. 60, n. 232, p. 1021-1029, 2011. ROCHA, J.R.; SANTOS, L.M. As vantagens da sexagen de embriões em bovinos. Revista científica eletrônica de medicina veterinária, ano IV, n.8, janeiro de 2007. RUBIN, M.I.B; Histórico dos 20 anos da Sociedade Brasileira de Tecnologia de Embriões, 2005. SANTOS, P.H. Impactos da superestimulação ovariana sore a diferenciação das celulas da grranulosa bovina. Dissertação de Mestrado em Farmacologia e Biotecnologia - UNESP. 2017. SEIDEL, G.E.J.; SEIDEL, S. M. Training manual for embryo transfer in cattle 2005. SENEDA, M.M.; ESPER, C.R.; GARCIA, J.M.; ANDRADE, E.R. Aspecto técnicos e biológicos da obtenção de oócitos bovinos: Revisão de Literatura. Ciências agrárias, Londrina, v. 23, n. 1, p. 101-110, 2002. SILVA, D.P.; TOLEDO, H.R.P.; SILVA, R.A.B.; CARVALHO, G.F.; MELO, A.F.; GARCIA, M.S.; et al. Transferência Intrafolicular de Ovócitos Imaturos (TIFOI): revisão de literatura. Zootecnia: Pesquisa e práticas contemporâneas - volume 2, 255-266, 2021. SPELL, A.R.; BEAL, W.E.; CORAH, L.R.; LAMB, G.C. Evaluating recipient and embryo factors that affect pregnancy rates of embryo transfer in beef cattle. Theriogenology, v. 56, p. 287-297, 2001. SPRÍCIGO, J.F.W.; DODE, M.A.N. Transferência Intrafolicular de Ovócitos Imaturos (TIFOI): uma Alternativa para Produção de Embriões Bovinos. Embrapa Recursos Genéticos e Biotecnologia, Brasília, 2016. VALLE, E.R. O ciclo estral de bovinos e os métodos de controle. EMBRAPA, 1991. VIANA, J.H.M. Classificação de embriões bovinos produzidos in vivo. Comunicado Técnico (EMBRAPA). ISSN 1678-3131, Juiz De Fora-MG, Novembro, 2009. VIANA, J.H.M. 2017 Statistics of embryo production and transfer in domestic farm animals: Is it a turning point? In 2017 more in vitro-produced than in vivo-derived embryos were transferred worldwide. Embryo Transfer Newsl, v.36(4), p.8-25, 2018. VIANA, J.H.M.; SIQUEIRA, L.G.; PALHAO, M.P.; CAMARGO, L.S.A.; Features and perspectives of the Brazilian in vitro embryo industry. Anim Reprod, v.9, p.12-18, 2012. WÜNSCHE JÚNIOR, A.G et al. Avaliação de uma segunda lavagem uterina sobre a recuperacão de embriões em vacas Nelore. Semina: Ciências Agrárias, Londrina, v. 29, n.3, p. 677-684, jul./set. 2008. (shrink)

Scholars have traditionally taken the Marquis de Sade to be a straightforward advocate of immoral hedonism. Without rejecting outright this view, I argue that Sade also presents an insightful theory of the psychology of pleasure, placing him amongst the more insightful psychological thinkers of the late 18th century. This paper outlines Sade’s description of the immoral will, in particular his account of how an agent can come to enjoy the humiliation, torture and murder of others. I argue for the following (...) claims: firstly, that Sade, perhaps despite himself, suggests that the sadistic will is pathological; secondly, that Sade’s work gives a far less flattering view of the sadistic will than is commonly supposed. (shrink)

Psychopaths routinely disregard social norms by engaging in selfish, antisocial, often violent behavior. Commonly characterized as mentally disordered, recent evidence suggests that psychopaths are executing a well-functioning, if unscrupulous strategy that historically increased reproductive success at the expense of others. Natural selection ought to have favored strategies that spared close kin from harm, however, because actions affecting the fitness of genetic relatives contribute to an individual’s inclusive fitness. Conversely, there is evidence that mental disorders can disrupt psychological mechanisms designed to (...) protect relatives. Thus, mental disorder and adaptation accounts of psychopathy generate opposing hypotheses: psychopathy should be associated with an increase in the victimization of kin in the former account but not in the latter. Contrary to the mental disorder hypothesis, we show here in a sample of 289 violent offenders that variation in psychopathy predicts a decrease in the genetic relatedness of victims to offenders; that is, psychopathy predicts an increased likelihood of harming non-relatives. Because nepotistic inhibition in violence may be caused by dispersal or kin discrimination, we examined the effects of psychopathy on (1) the dispersal of offenders and their kin and (2) sexual assault frequency (as a window on kin discrimination). Although psychopathy was negatively associated with coresidence with kin and positively associated with the commission of sexual assault, it remained negatively associated with the genetic relatedness of victims to offenders after removing cases of offenders who had coresided with kin and cases of sexual assault from the analyses. These results stand in contrast to models positing psychopathy as a pathology, and provide support for the hypothesis that psychopathy reflects an evolutionary strategy largely favoring the exploitation of non-relatives. (shrink)

What is sexual orientation? The contemporary consensus among philosophers is that it is a disposition. Unsurprisingly, recent debates about the metaphysics of sexual orientation are almost entirely intramural. Behavioral dispositionalists argue that sexual orientation is a disposition to behave sexually. Desire dispositionalists argue that it is a disposition to desire sexually. We argue that sexual orientation is not best understood in terms of dispositions to behave or dispositions to desire before arguing that dispositions tout court fail to illuminate sexual orientation. (...) We then introduce and defend the idea that sexual orientation is best understood in terms of categorical phenomenal properties of sexual arousal. (shrink)

A gas in a box is perhaps the most important model system studied in thermodynamics and statistical mechanics. Usually, studies focus on the gas, whereas the box merely serves as an idealized confinement. The present article focuses on the box as the central object and develops a thermodynamic theory by treating the geometric degrees of freedom of the box as the degrees of freedom of a thermodynamic system. Applying standard mathematical methods to the thermody- namics of an empty box allows (...) equations with the same structure as those of cosmology and classical and quantum mechanics to be derived. The simple model system of an empty box is shown to have interesting connections to classical mechanics, special relativity, and quantum field theory. (shrink)

Ethical decision-making frameworks assist in identifying the issues at stake in a particular setting and thinking through, in a methodical manner, the ethical issues that require consideration as well as the values that need to be considered and promoted. Decisions made about the use, sharing, and re-use of big data are complex and laden with values. This paper sets out an Ethics Framework for Big Data in Health and Research developed by a working group convened by the Science, Health and (...) Policy-relevant Ethics in Singapore Initiative. It presents the aim and rationale for this framework supported by the underlying ethical concerns that relate to all health and research contexts. It also describes a set of substantive and procedural values that can be weighed up in addressing these concerns, and a step-by-step process for identifying, considering, and resolving the ethical issues arising from big data uses in health and research. This Framework is subsequently applied in the papers published in this Special Issue. These papers each address one of six domains where big data is currently employed: openness in big data and data repositories, precision medicine and big data, real-world data to generate evidence about healthcare interventions, AI-assisted decision-making in healthcare, public-private partnerships in healthcare and research, and cross-sectoral big data. (shrink)

RESUMO Os cuidados para atender às necessidades específicas da fêmea gestante são indispensáveis para o sucesso no manejo reprodutivo de qualquer espécie. Entretanto, é necessário entender que podem acontecer problemas em qualquer uma das fases reprodutivas, inclusive na gestação. Antes de tudo, na clínica e na produção, a sobrevivência dos fetos significa êxito no manejo reprodutivo. Durante o período gestacional podem se desenvolver diversas afecções no útero da fêmea, dentre elas podem ser citadas: mumificação fetal, gravidez ectópica, maceração fetal, prenhez (...) múltipla patológica e diversas anomalias que podem acometer os envoltórios e líquidos fetais. Essas doenças representam prognóstico ruim para a fêmea e para o feto, podendo resultar em perdas fetais. O conhecimento acerca das características dessas afecções, bem como a fisiopatologia e diagnóstico são indispensáveis para o sucesso da reprodução animal. Palavras-chave: Ginecologia, reprodução, gestação. ABSTRACT Care to meet the specific needs of pregnant females is essential for the successful reproductive management of any species. However, it is necessary to understand that problems may occur in any of the reproductive stages, including pregnancy. First of all, in the clinic and production, the survival of fetuses means success in reproductive management. During the gestational period, several pathological conditions can develop in the female uterus, among them fetal mummification, ectopic pregnancy, fetal maceration, pathological multiple pregnancy, and the various anomalies that can affect fetal envelopes and fluids. These illnesses represent a poor prognosis for the female and the fetus and may result in fetal loss. Knowledge about the characteristics of these conditions, as well as the pathophysiology and diagnosis are essential for the success of animal reproduction. Keywords: Gynecology, reproduction, gestation. -/- INTRODUÇÃO Na fisiologia da reprodução nos mamíferos, a implantação e a placentação são processos essenciais na nutrição do embrião e do feto e do seu desenvolvimento. Nos bovinos leiteiros, estima-se uma taxa de fertilização de 95%, com apenas 55% desses zigotos se desenvolvendo a termo e com perda de gestações de 35% (SILVA, 2021). Em equinos varia entre 5 e 15% (BRINSKO et al., 2011) e em suínos chega a 40% (VAN DER LENDE et al., 1994). A reprodução permite a manutenção do equilíbrio biótico, entretanto, falhas podem ocorrer, desde a concepção até o parto, incapacitando o pleno desenvolvimento gestacional e acarretando danos à cadeia produtiva (BRAGA e BARROSO, 2014). A taxa de perda gestacional atinge o pico durante o desenvolvimento embrionário e diminui após 45 dias, à medida que a gestação progride e a placentação ativa está completa (REESE et al., 2020). A placenta permite contato vascular eficaz entre as membranas fetais e o endométrio materno, através do qual ocorre a troca de oxigênio e de nutrientes vindos pelo sangue materno, além dos produtos de excreção do sangue fetal. Ela apresenta quatro membranas: a) âmnio, que contém o fluido amniótico que banha o embrião; b) saco vitelínico, que armazena os nutrientes; c) saco alantoide, onde os restos do metabolismo embrionário são estocados e d) córion, que delimita os limites do embrião e interage seletivamente com o ambiente externo, permitindo nutrientes e/ou oxigênio cheguem ao embrião (SILVA, 2020). No aparelho reprodutivo feminino as estruturas internas são presas pelo ligamento mesovário, que sustenta o ovário; o mesossalpinge, que ancora o oviduto e o mesométrio, que mantém o útero no seu lugar. Ele compreende os ovários, tubas, útero, cérvix, vagina, vestíbulo e vulva (KÖNIG e LIEBICH, 2021). O útero é formado por dois cornos, na região mesogástrica, que formam o corpo uterino, dorsal a vesícula urinária e ventral ao cólon descendente (PINTO e LORIGADOS, 2015). A cérvix fica na região caudal do útero (DYCE, 2019) e é composta pelo óstio uterino interno e o externo (KÖNIG e LIEBICH, 2021). O líquido amniótico é um complexo biológico que proporciona proteção mecânica, nutrientes e substâncias para o crescimento fetal e possui efeito antimicrobiano (UNDERWOOD et al., 2005). Ele desempenha várias funções: protege o feto contra traumas, desidratação e mudanças de temperatura; permite o desenvolvimento fetal e sua mobilidade; amplia a lubrificação da vagina após a ruptura da bolsa, inibe o crescimento bacteriano por ação mecânica de limpeza e previne aderências (GRUNERT e BIRGEL, 1984). As enfermidades do trato reprodutivo têm causado problemas reprodutivos, acarretando perdas econômicas (JÚNIOR et al., 2009). Os problemas na esfera da fisiopatologia da reprodução em animais, está associada ao período do periparto (SCOTT, 2005). Entretanto, existem relatos de sua ocorrência em fêmeas não gestantes e também fora do período puerperal (PRESTES et al., 2008; SALES et al., 2011). Devido à importância das diversas patologias que atingem o útero gravídico, esse trabalho tem como objetivo buscar identificar na literatura científica existente as características, diagnóstico e tratamento de cada alteração uterina, pautando discussão crítica sobre os processos de formação de cada uma. (shrink)

As moral injury is a still-emerging concept within the area of military mental health, prevalence estimates for moral injury and its precursor, potentially morally injurious events (PMIEs), remain unknown for many of the world’s militaries. The present study sought to estimate the prevalence of PMIEs in the Canadian Armed Forces (CAF), using data collected from CAF personnel deployed to Afghanistan, via logistic regressions controlling for relevant sociodemographic, military, and deployment characteristics. Analyses revealed that over 65% of CAF members reported exposure (...) to at least one event that would be considered a PMIE. The most commonly PMIEs individuals reported included seeing ill or injured women and children they were unable to help (48.4%), being unable to distinguish between combatants and non-combatants (43.6%), and finding themselves in a threatening situation where they were unable to respond due to the rules of engagement under which they were required to operate (35.4%). These findings provide support for both the presence of exposure to PMIEs in CAF members and the need for formal longitudinal data collection regarding PMIE exposure and moral injury development. (shrink)

This study aimed to unveil the sentiments of college students' feedback on their teacher's teaching performance during online classes. The research utilized a qualitative approach, explicitly employing text mining. Orange software determined the most frequently used words illustrating teachers' teaching performance during online courses. Moreover, Latent Semantic Indexing (LSI) was utilized to reveal how those frequently used words were structured. Meanwhile, the study showed that the words "teacher," "class," "us," "student," "online," "teaching," "happy," "learning," "understand," and "good" were most frequently (...) used in college students' sentiments regarding their teacher's performance during online classes. The study also indicated that most students have positive feedback on their teachers' teaching performance in online courses. Therefore, the findings suggest that teachers have the abilities and knowledge to successfully impart lessons to their students despite the enormous dilemma the pandemic has brought about in every sector, especially in education. (shrink)

This study sought to investigate the Human Resource and Management (HRM) Program of a preschool hereinafter referred to as the Early Years Learning Center (EYLC) in Mandaluyong City for purposes of this research study. This is a qualitative case study that delved particularly into the issue of employee retention, especially of seasoned teachers and staff of the subject learning center. It used the interview method to generate an in-depth analysis as it revisited its HRM Program. To triangulate the data gathered, (...) documents from websites and social media as well as artifacts were also utilized. There is a dearth of research on the Human Resource and Management Program in preschool education. Most studies are from India and China. In terms of the HRM Program in education, SWOT analysis was frequently used to help improve the program. There were negligible sources that used the balanced scorecard at the preschool level. Hence, a combination of the SWOT analysis and the Balanced Scorecard method were utilized - the SWOT Analysis to determine the problems the learning center faces vis-à-vis its HRM Program, and the balanced scorecard in the search for a solution or strategy to help solve the problem. Based on the study, these combined tools proved to be effective in revisiting the HRM Program of schools. After interviewing the Directress of EYLC, findings disclosed that to be able to improve the retention of employees in the learning center, the focus should be given to the hiring policies and procedures keeping in mind the job security of its targeted employees. This brings forward concerns over advertising schemes utilizing different venues and platforms as well as issues involving the provision of seasoned employees with a retirement package, comprehensive Health Management Organization (HMO), and a continuing professional development program. (shrink)

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) -/- Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems.

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

This study investigates strategies for hotels situated near Taal Volcano to lessen the impact of natural disasters, specifically volcanic eruptions. The hospitality industry in this region faces a unique threat due to the volcano's activity. This research addressed a critical gap by implementing effective preparedness and response plans. A qualitative multiple case study design was employed by the researchers. Seven (7) hotel executives from different hotels situated in Batangas who had directly encountered and navigated the impacts of natural disasters were (...) selected through the purposive sampling technique. The findings revealed several common natural hazards faced by hotels include Taal volcano eruptions, typhoons, earthquakes, ashfall, and sulfur dioxide emissions. Despite of this natural hazards, hotel executives were still capable of safeguarding their guests by implementing strategies including evacuation procedures, staff training, communication and coordination and preventive measures. In conclusion, to overcome the challenges identified in disaster preparedness, hotels in Batangas should consider several strategic actions. Hotels are recommended to take several crucial actions to enhance their preparedness and response capabilities to natural hazards. Adhering to safety regulations will help hotels maintain a high level of preparedness and minimize risks associated with natural hazards, ultimately safeguarding the well-being of guests and staff alike. (shrink)

There is growing interest in the use of technology to enhance the tracking and quality of clinical information available for patients in disaster settings. This paper describes the design and evaluation of the Wireless Internet Information System for Medical Response in Disasters (WIISARD).

Green buildings are an integral part of the solution to the environmental challenges facing the planet. Today we use the equivalent of 1.5 Earths to meet the resource needs of everyday life and absorb the resulting wastes. This measure of our planet’s carrying capacity means that it takes Earth 18 months to regenerate what is used in only 12 months. If current trends continue, estimates suggest, by the year 2030 we will need the equivalent of two planets. Turning resources into (...) waste faster than they can be regenerated puts the planet into ecological overshoot, a clearly unsustainable condition that we all must address. The forces driving this situation are numerous. Human population has increased exponentially in the past 60 years, from about 2.5 billion in 1950 to more than 7 billion todays. Our linear use of resources, treating outputs as waste, is responsible for the toxins that are accumulating in the atmosphere, in water, and on the ground. This pattern of extraction, use, and disposal has hastened depletion of finite supplies of non-renewable energy, water, and materials and is accelerating the pace of our greatest problem—climate change. (shrink)

Despite the apparent relationship between personal values and entrepreneurship, this topic t has been subject to little academic research. This article aims to explain, in the Brazilian context, how the personal values of entrepreneurs influence the degree of professionalism in their business. The article uses a descriptive and exploratory quantitative approach, with data collected via a survey and focus group. Results show that, in the Brazilian context, ethics and capitalist values have a greater influence on professionalism than do risk, innovation, (...) family history, etc. Certain personal values of small-business entrepreneurs become organizational values that drive their actions in challenging environments. The finding that only one of the ten independent variables has been considered statistically influential on professionalism constitutes its main theoretical contribution. It rethinks professionalism, no longer as a dependent variable, but as a personal value, like the rest, in independent, innovative and sovereign way. (shrink)

Kit Fine (2000) breaks with tradition, arguing that, pace Russell (e.g., 1903: 228), relations have neither directions nor converses. He considers two ways to conceive of these new "neutral" relations, positionalism and anti-positionalism, and argues that the latter should be preferred to the former. Cody Gilmore (2013) argues for a generalization of positionalism, slot theory, the view that a property or relation is n-adic if and only if there are exactly n slots in it, and (very roughly) that each slot (...) may be occupied by at most one entity. Slot theory (and with it, positionalism) bears the full brunt of Fine's (2000) symmetric completions and conflicting adicities problems. I fully develop an alternative, plural slot theory (or pocket theory), which avoids these problems, key elements of which are first considered by Yi (1999: 168 ff.). Like the slot theorist, the pocket theorist posits entities (pockets) in properties and relations that can be occupied. But unlike the slot theorist, the pocket theorist denies that at most one entity can occupy any one of them. As a result, she must also deny that the adicity of a property or relation is equal to the number of occupiable entities in it. By abandoning these theses, however, the pocket theorist is able to avoid Fine's problems, resulting in a stronger theory about the internal structure of properties and relations. Pocket theory also avoids a serious drawback of anti-positionalism. (shrink)

Moral enhancement is an ostensibly laudable project. Who wouldn’t want people to become more moral? Still, the project’s approach is crucial. We can distinguish between two approaches for moral enhancement: direct and indirect. Direct moral enhancements aim at bringing about particular ideas, motives or behaviors. Indirect moral enhancements, by contrast, aim at making people more reliably produce the morally correct ideas, motives or behaviors without committing to the content of those ideas, motives and/or actions. I will argue, on Millian grounds, (...) that the value of disagreement puts serious pressure on proposals for relatively widespread direct moral enhancement. A more acceptable path would be to focus instead on indirect moral enhancements while staying neutral, for the most part, on a wide range of substantive moral claims. I will outline what such indirect moral enhancement might look like, and why we should expect it to lead to general moral improvement. (shrink)

Are words like ‘woman’ or ‘man’ sex terms that we use to talk about biological features of individuals? Are they gender terms that we use to talk about non-biological features e.g. social roles? Contextualists answer both questions affirmatively, arguing that these terms concern biological or non-biological features depending on context. I argue that a recent version of contextualism from Jennifer Saul that Esa Diaz-Leon develops doesn't exhibit the right kind of flexibility to capture our theoretical intuitions or moral and political (...) practices concerning our uses of these words. I then float the view that terms like 'woman' or 'man' are polysemous, arguing that it makes better sense of the significance of some forms of criticisms of mainstream gender ideology. (shrink)

Many feminists (e.g. T. Bettcher and B. R. George) argue for a principle of first person authority (FPA) about gender, i.e. that we should (at least) not disavow people's gender self-categorisations. However, there is a feminist tradition resistant to FPA about gender, which I call "radical feminism”. Feminists in this tradition define gender-categories via biological sex, thus denying non-binary and trans self-identifications. Using a taxonomy by B. R. George, I begin to demystify the concept of gender. We are also able (...) to use the taxonomy to model various feminist approaches. It becomes easier to see how conceptualisations ofgender which allow for FPA often do not allow for understanding female subjugation as being rooted in reproductive biology. I put forward a conceptual scheme: radical FPA feminism. If we accept FPA, but also radical feminist concerns, radical FPA feminism is an attractive way of conceptualising gender. (shrink)

Meillassoux seeks knowledge of transcendental reality, blaming Kant for the ‘correlationist’ proscription of independent access to either thought or being. For Meillassoux, correlationism blocks an account of the meaning of ‘ancestral statements’ regarding reality prior to humans. I examine three charges on which Meillassoux’s argument depends: (1) Kant distorts ancestral statements’ meaning; (2) Kant fallaciously infers causality’s necessity; (3) Kant’s transcendental idealism cannot grasp ‘the great outdoors’. I reject these charges: (1) imposes a Cartesian misreading, hence Meillassoux’s false assumption that, (...) for Kant, objects don’t exist without subjects; (2) misreads Kant, who infers causality’s necessity from the possibility of experience; (3) casts Kant’s idealism as subjective, ignoring his perspectival portrayal of it. (shrink)

To most of us – believers and non-believers alike – the possibility of a perfect God co-existing with the kinds of evil that we see calls out for explanation. It is unsurprising, therefore, that the belief that God must have justifying reasons for allowing all the evil that we see has been a perennial feature of theistic thought. Recently, however, a growing number of authors have argued that the existence of a perfect God is compatible with the existence of gratuitous (...) evil. Given powerful, millenia-long sensibilities about power and love and justice, it isn’t hard to find that suggestion simply incredible. Nonetheless, in this paper I will argue that the most prominent theistic alternatives to what has seemed incredible to most of us throughout most of history are themselves patently unacceptable for the theist as well. On any of the most widely accepted accounts of how God could have justifying reasons for permitting some evils, God’s existence means that we have justifying reasons for perpetrating and allowing every evil that we see. That's hard to swallow too. If I’m right about all of this, then two competing outcomes seem to present themselves as a possible result. On the one hand, for the theist, the apparently outrageous suggestion that the existence of a perfect God is compatible with gratuitous evil no longer looks like it faces a formidable, hard-to-resist alternative. On the other hand, some like me might think that my arguments go no distance at all towards dispelling the incredibility of the gratuitous evil nouvelle vague. On this line, theism may seem now to be between the rock and the hard place: it seems hard to make sense of the existence of a perfect God whether or not He has justifying reasons for allowing all the evil that we see. (shrink)

Whilе thе rоbust аnd pоsitivе аssоciаtiоn bеtwееn еducаtiоn аnd pоliticаl еngаgеmеnt hаs bееn widеly dоcumеntеd, thе dirеct cаusаl link is still а subjеct оf dеbаtе. This study cоntributеs tо thе оngоing dеbаtе by еxаmining whеthеr thеrе еxists а cаusаl еffеct оf еducаtiоn оn pоliticаl еngаgеmеnt. Explоiting thе plаusibly еxоgеnоus vаriаtiоn in еducаtiоn inducеd by thе cоmpulsоry schооling rеfоrms аcrоss 39 cоuntriеs, wе find thаt еducаtiоn cultivаtеs pоliticаl intеrеst, prоmоtеs thе аcquisitiоn оf pоliticаl knоwlеdgе, аnd fоstеrs suppоrtivе аttitudеs tоwаrds pоliticаl frееdоms. (...) Nеvеrthеlеss, thе bеttеr еducаtеd аrе nо mоrе likеly tо vоtе in еlеctiоns nоr аdоpt аny spеcific pоsitiоn in thе lеft-right pоliticаl spеctrum. (shrink)

RESUMO A alimentação é o fator que mais onera um sistema de produção animal. Assim, a utilização de diferentes estratégias de alimentação dos animais ainda é o grande desafio da nutrição animal, principalmente, levando em consideração as exigências nutricionais de diferentes categorias de ruminantes, em especial bovinos em regiões tropicais, haja vista que a sazonalidade na produção de forragens afeta diretamente a produção bovina, promovendo inadequação no atendimento das exigências nutricionais dos animais principalmente em minerais e vitaminas. Uma alimentação que (...) não atenda as exigências nutricionais dos ruminantes gera prejuízos no sistema de produção, além de, em casos mais graves, ocasionar a perda do animal. Estudos que abordam o efeito e a importância de vitaminas e minerais na nutrição bovina são escassos e necessários. Recentemente a National Research Council (NRC) apresentou novos registros das exigências nutricionais das vitaminas e minerais. Essas alterações proporcionam um impacto econômico significativo em relação à nutrição animal. Nesse sentido, objetivou-se com esta revisão trazer informações acerca de vitaminas e minerais na nutrição de bovinos em pastejo. -/- Palavras-chave: Alimentação animal; forragem; pastagem; requerimentos nutricionais; ruminantes; vitaminas lipossolúveis (Source: AGROVOC). -/- ABSTRACT Animal feed is the factor that most burdens a production system. Thus, the use of different animal feeding strategies is still the great challenge of animal nutrition, taking into account the nutritional requirements of different categories of ruminants, especially cattle in tropical regions, given that seasonality in forage production directly affects cattle production, promoting inadequacy in meeting the nutritional requirements of animals, mainly in minerals and vitamins. A diet that does not meet the nutritional requirements of ruminants generates losses in the production system, in addition to, in more serious cases, causing the loss of the animal. Studies that address the effect and importance of vitamins and minerals in bovine nutrition are scarce and necessary. Recently the National Research Council (NRC) presented new records of the nutritional requirements of vitamins and minerals. These changes provide a significant economic impact on animal nutrition. In this sense, the objective of this review was to bring information about vitamins and minerals in the nutrition of grazing cattle. -/- Keywords: Animal feeding; fat soluble vitamins; forage; nutritional requirements; pasture feeding; ruminants (Source: AGROVOC). -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- 1. Cavalcanti CPL, Silva e Macedo TJ, Gois GC, Menezes VG, Monte APO, Silva AD, Silva DJM, Silva EO, Araújo GGL, Rodrigues RTS, Wischral A, Matos MHT, Queiroz MAA. 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A review of vitamin D and its importance to the health of dairy cattle. J Dairy Res. 2020; 87:84–87. 50. Alves EM, Pedreira MS, Santana CA, Silva FF. Nutrição vitamínica de vacas leiteiras. Pubvet. 2008; 2:1-17. 51. Jiang Q, Lin L, Xie F, Jin W, Zhu W, Wang M, et al. Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants. Microb. 2022; 10:1-16. 52. Magan JB, O’Callaghan TF, Zheng J, Zhang L, Mandal R, Hennessy D, et al. Effect of diet on the vitamin B profile of bovine milk-based protein ingredients. Foods. 2020; 9:1-17. 53. Pinedo LA, Berenchtein B, Selem ASMA. Estudo dos processos bioquímicos da fermentação, degradação e absorção de nutrientes dos alimentos em ruminantes. Pubvet. 2008; 2:1-10. 54. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. 55. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. 56. DA SILVA, Emanuel Isaque Cordeiro. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. (shrink)

Hartry Field has suggested that we should adopt at least a methodological deflationism: [W]e should assume full-fledged deflationism as a working hypothesis. That way, if full-fledged deflationism should turn out to be inadequate, we will at least have a clearer sense than we now have of just where it is that inflationist assumptions ... are needed. I argue here that we do not need to be methodological deflationists. More pre-cisely, I argue that we have no need for a disquotational truth-predicate; (...) that the word true, in ordinary language, is not a disquotational truth-predicate; and that it is not at all clear that it is even possible to introduce a disquotational truth-predicate into ordinary language. If so, then we have no clear sense how it is even possible to be a methodological deflationist. My goal here is not to convince a committed deflationist to abandon his or her position. My goal, rather, is to argue, contrary to what many seem to think, that reflection on the apparently trivial character of T-sentences should not incline us to deflationism. (shrink)

The 'substitution argument' purports to demonstrate the falsity of Russellian accounts of belief-ascription by observing that, e.g., these two sentences: (LC) Lois believes that Clark can fly. (LS) Lois believes that Superman can fly. could have different truth-values. But what is the basis for that claim? It seems widely to be supposed, especially by Russellians, that it is simply an 'intuition', one that could then be 'explained away'. And this supposition plays an especially important role in Jennifer Saul's defense of (...) Russellianism, based upon the existence of an allegedly similar contrast between these two sentences: (PC) Superman is more popular than Clark. (PS) Superman is more popular than Superman. The latter contrast looks pragmatic. But then, Saul asks, why shouldn't we then say the same about the former? The answer to this question is that the two cases simply are not similar. In the case of (PC) and (PS), we have only the facts that these strike us differently, and that people will sometimes say things like (PC), whereas they will never say things like (PS). By contrast, there is an argument to be given that (LS) can be true even if (LC) is false, and this argument does not appeal to anyone's 'intuitions'. The main goal of the paper is to present such a version of the substitution argument, building upon the treatment of the Fregan argument against Russellian accounts of belief itself in "Solving Frege's Puzzle". A subsidiary goal is to contribute to the growing literature arguing that 'intuitions' simply do not play the sort of role in philosophical inquiry that so-called 'experimental philosophers' have supposed they do. (shrink)

While philosophers hold that it is patently absurd to blame robots or hold them morally responsible [1], a series of recent empirical studies suggest that people do ascribe blame to AI systems and robots in certain contexts [2]. This is disconcerting: Blame might be shifted from the owners, users or designers of AI systems to the systems themselves, leading to the diminished accountability of the responsible human agents [3]. In this paper, we explore one of the potential underlying reasons for (...) robot blame, namely the folk's willingness to ascribe inculpating mental states or "mens rea" to robots. In a vignette-based experiment (N=513), we presented participants with a situation in which an agent knowingly runs the risk of bringing about substantial harm. We manipulated agent type (human v. group agent v. AI-driven robot) and outcome (neutral v. bad), and measured both moral judgment (wrongness of the action and blameworthiness of the agent) and mental states attributed to the agent (recklessness and the desire to inflict harm). We found that (i) judgments of wrongness and blame were relatively similar across agent types, possibly because (ii) attributions of mental states were, as suspected, similar across agent types. This raised the question - also explored in the experiment - whether people attribute knowledge and desire to robots in a merely metaphorical way (e.g., the robot "knew" rather than really knew). However, (iii), according to our data people were unwilling to downgrade to mens rea in a merely metaphorical sense when given the chance. Finally, (iv), we report a surprising and novel finding, which we call the inverse outcome effect on robot blame: People were less willing to blame artificial agents for bad outcomes than for neutral outcomes. This suggests that they are implicitly aware of the dangers of overattributing blame to robots when harm comes to pass, such as inappropriately letting the responsible human agent off the moral hook. (shrink)

The purpose of this note is to present a strong form of the liar paradox. It is strong because the logical resources needed to generate the paradox are weak, in each of two senses. First, few expressive resources required: conjunction, negation, and identity. In particular, this form of the liar does not need to make any use of the conditional. Second, few inferential resources are required. These are: (i) conjunction introduction; (ii) substitution of identicals; and (iii) the inference: From ¬(p (...) ∧ p), infer ¬ p. It is, interestingly enough, also essential to the argument that the ‘strong’ form of the diagonal lemma be used: the one that delivers a term λ such that we can prove: λ = ¬ T(⌈λ⌉); rather than just a sentence Λ for which we can prove: Λ ≡ ¬T(⌈Λ⌉). The truth-theoretic principles used to generate the paradox are these: ¬(S ∧ T(⌈¬S⌉); and ¬(¬S ∧ ¬T(⌈¬S⌉). These are classically equivalent to the two directions of the T-scheme, but they are intuitively weaker. The lesson I would like to draw is: There can be no consistent solution to the Liar paradox that does not involve abandoning truth-theoretic principles that should be every bit as dear to our hearts as the T-scheme. So we shall have to learn to live with the Liar, one way or another. (shrink)

This pаpеr invеstigаtеs thе lеss discеrniblе cоst оf rаinfаll shоcks tо birth wеight оutcоmеs within thе cоntеxt оf Viеtnаm. Еxplоiting thе vаriаtiоn аcrоss districts аnd cоncеptiоn mоnths-yеаrs, wе shоw thаt in-utеrо еxpоsurе tо еxcеssivе аnd dеficiеnt rаinfаll shоcks in thе sеcоnd trimеstеr оf prеgnаncy rеducеs child’s wеight аt birth by 3.5 аnd 3.1%, rеspеctivеly. Bеsidеs, infаnts bоrn tо pооr, rurаl, аnd lоw еducаtеd mоthеrs аrе еspеciаlly vulnеrаblе tо thе аdvеrsе rеpеrcussiоns оf rаinfаll shоcks. Sincе pооr infаnt hеаlth cаn lеаvе pеrsistеnt (...) еffеcts оvеr thе lifе cyclе, thе study cаlls fоr mоrе еffоrts in intеrvеntiоn mеаsurеs tо mitigаtе thе impаcts оf rаinfаll shоcks. Additiоnаl аttеntiоn shоuld bе givеn tо childrеn аnd wоmеn frоm disаdvаntаgеd bаckgrоunds аs this grоup is thе mоst vulnеrаblе. (shrink)

Thе еxprоpriаtiоn оf аgriculturаl lаnd tо prоvidе nеw lаnd fоr industriаl аnd urbаn еxpаnsiоn, rеfеrrеd tо аs cоmpulsоry аcquisitiоn, is prеvаlеnt in dеvеlоping cоuntriеs. Using Viеtnаm аs а lаbоrаtоry, this study еvаluаtеs thе impаcts оf lоsing fаrmlаnd thrоugh cоmpulsоry аcquisitiоn оn hоusеhоld wеlfаrе аnd rеаchеs thе fоllоwing findings. A 10 pеrcеntаgе pоint incrеаsе in thе prоpоrtiоn оf lаnd еxprоpriаtеd rеsults in а 2.2% dеcrеаsе in hоusеhоld wеlfаrе prоxiеd by fооd еxpеnditurе. Bеsidеs, pоliticаlly uncоnnеctеd аnd еthnic minоrity hоusеhоlds аrе disprоpоrtiоnаtеly vulnеrаblе. (...) Thе аdvеrsе wеlfаrе еffеct cоuld tаkе up tо 10 yеаrs tо еvаpоrаtе. Thе rеductiоn in hоusеhоld wеlfаrе is аttributаblе tо thе dеclinе in аgriculturаl incоmе аnd thе inаbility tо pаrticipаtе in thе nоn-аgriculturаl lаbоr mаrkеt. Othеr аspеcts оf hоusеhоld bеhаviоr fоllоwing cоmpulsоry аcquisitiоn аrе аlsо еxplоrеd, such аs sаving, sоciаl cаpitаl, lаbоr, аnd cаpitаl аllоcаtiоn. (shrink)

Evidential Uniqueness is the thesis that, for any batch of evidence, there’s a unique doxastic state that a subject with that evidence should have. One of the most common kinds of objections to views that violate Evidential Uniqueness are arbitrariness objections – objections to the effect that views that don’t satisfy Evidential Uniqueness lead to unacceptable arbitrariness. The goal of this paper is to examine a variety of arbitrariness objections that have appeared in the literature, and to assess the extent (...) to which these objections bolster the case for Evidential Uniqueness. After examining a number of different arbitrariness objections, I’ll conclude that, by and large, these objections do little to bolster the case for Evidential Uniqueness. (shrink)

Examining the historical development of scientific concepts is important for understanding the structured routines within which these concepts are currently used as goal-directed tools in experiments. To illustrate this claim, I will outline how the concepts of mental imagery and hallucinations each draw on an older interdependent set of associations that, although nominally-discarded, continues to structure their current independent uses for pursuing discrete experimental goals. In doing so, I will highlight how three strands of literature offer mutually instructive insights for (...) understanding how the uses of our current scientific concepts contribute to experimental practices. The first strand of literature includes recent scholarship examining how the uses of scientific concepts can enable scientific practices (e.g., Boon 2012; Brigandt 2012; Feest 2010; Steinle 2012). In this context, scientific concepts have been described as tools that function in ways that contribute to empirical knowledge; contributions that extend beyond their traditionally recognized roles in mental and linguistic representation. The second strand of literature can be glimpsed within the technoscientific studies focus on non-human agency; a focus that supports an account of the disciplined routines within which concepts are used as acting in analogous ways to the routinized participation of machines in experiments (Pickering 1995). The third strand of the literature draws attention to how the functions of concepts are grounded by the set of historically-contingent experimental practices (e.g., Canguilhem 2008; Tiles 1984). Although maintaining valuable differences, the focus of these three strands of literature are mutually instructive. Together, they offer a view of the uses of concepts as taken-for-granted tools that function within networks of subterranean associations; associations that are grounded by historically contingent experimental practices that structure how they act (in concert with human and material participants) within the temporally dynamic processes of scientific practice. Through examples drawn from a comparison of the concepts of mental imagery and hallucinations, I aim to demonstrate the value that the converging insights of these three strands of literature offer for studying the role of scientific concepts in experimental practices. (shrink)

This article is a rebuttal to Robert G. Cavin and Carlos A. Colombetti’s article, “Assessing the Resurrection Hypothesis: Problems with Craig’s Inference to the Best Explanation,” which argues that the Standard Model of current particle physics entails that non-physical things (like a supernatural God or a supernaturally resurrected body) can have no causal contact with the physical universe. As such, they argue that William Lane Craig’s resurrection hypothesis is not only incompatible with the notion of Jesus physically appearing to the (...) disciples, but the resurrection hypothesis is significantly limited in both its explanatory scope and explanatory power. This article seeks to demonstrate why their use of the Standard Model does not logically entail a rejection of the physical resurrection of Jesus when considering the scope and limitations of science itself. (shrink)

What I call the Doxastic Puzzle, is the impression that while each of these claims seems true, at least one of them must be false: (a) Claims of the form ‘S ought to have doxastic attitude D towards p at t’ are sometimes true at t, (b) If Φ-ing at t is not within S’s effective control at t, then it is false, at t, that ‘S ought to Φ at t’, (c) For all S, p, and t, having doxastic (...) attitude D towards p at t is not within S’s effective control at t. All three natural replies to the puzzle have been pursued. Some have claimed that doxastic attitudes like believing that p are, in fact, within our effective control, or sufficiently so. Others have claimed that doxastic ought-claims, strictly speaking, are always false. And some have denied that effective control is required for the adequacy of doxastic ought-claims in general. I here pursue and examine a different strategy. In the first part of this paper, I argue that these claims are not only each true but actually not in tension with each other in the first place. Instead of attempting to dispel the puzzle, this solution proposes to evade it instead: to solve it by properly understanding, and by thereby accepting without contradiction, all of its constitutive claims. In the second part of the paper, I argue that the evasive strategy forces us to re-think our understanding of the place of normative reasons in epistemology. More exactly, it seems to come at the cost of one central way of thinking about our reasons for having doxastic attitudes, one where such reasons are good-standing exemplars of normative reasons in general. The evasive strategy, that is, threatens to lead us very quickly to a deflationary picture of epistemic normativity: it rescues normative talk, but sacrifices normative substance. I conclude by explaining why I think this is more consequential than some have made it out to be, and by suggesting that these consequences are welcome nonetheless. (shrink)

The world of entrepreneurship has historically been linked with taking risks and the potential for significant rewards. However, there persists a notable gender imbalance in the entrepreneurial landscape, wherein women entrepreneurs remain a minority. Women navigating the entrepreneurial path encounter distinct challenges, setting their experiences apart from their male counterparts. In Balayan, Batangas, despite strides towards gender equality, women entrepreneurs continue to face challenges in the entrepreneurial landscape. This qualitative study delves into the experiences of 10 successful female entrepreneurs who (...) met specific criteria. Accordingly, semi-structured interviews are conducted, exploring various aspects of participants' experiences and revealing their motivations, achievements, challenges, and strategies. Thematic analysis reveals the connection between familial, community-driven, and personal motivations that drive these entrepreneurs forward. Despite facing obstacles such as financial constraints and gender biases, they prioritize financial gains and personal growth. With resilience, innovation, and dedication, these women overcome challenges and achieve success, utilizing support networks and online marketing strategies to their advantage. Recommendations include empowering women in entrepreneurship, strengthening support networks, introducing tailored financial literacy programs, and advocating against gender biases. Implement skill development initiatives and provide specialized education in online marketing. Engage in policy advocacy, celebrate success stories, and continuously research challenges and successes. Foster collaborative partnerships between businesses, educational institutions, and communities, and advocate for increased funding opportunities for sustainable growth. This research emphasizes the strength and capabilities of women entrepreneurs in Balayan, Batangas, affirming that "pink doesn't mean weak.". (shrink)

Whilе thе rоbust аnd pоsitivе аssоciаtiоn bеtwееn еducаtiоn аnd pоliticаl еngаgеmеnt hаs bееn widеly dоcumеntеd, thе dirеct cаusаl link is still а subjеct оf dеbаtе. This study cоntributеs tо thе оngоing dеbаtе by еxаmining whеthеr thеrе еxists а cаusаl еffеct оf еducаtiоn оn pоliticаl еngаgеmеnt. Explоiting thе plаusibly еxоgеnоus vаriаtiоn in еducаtiоn inducеd by thе cоmpulsоry schооling rеfоrms аcrоss 39 cоuntriеs, wе find thаt еducаtiоn cultivаtеs pоliticаl intеrеst, prоmоtеs thе аcquisitiоn оf pоliticаl knоwlеdgе, аnd fоstеrs suppоrtivе аttitudеs tоwаrds pоliticаl frееdоms. (...) Nеvеrthеlеss, thе bеttеr еducаtеd аrе nо mоrе likеly tо vоtе in еlеctiоns nоr аdоpt аny spеcific pоsitiоn in thе lеft-right pоliticаl spеctrum. (shrink)

Thomas Hurka’s recursive account of value appeals to certain intuitions to expand the class of intrinsic values, placing concepts of virtue and desert within the realm of second and third order intrinsic goods, respectively. This is a formalization of a tradition of thought extending back to Aristotle and Kant via the British moralists, G. E. Moore, and W. D. Ross. However, the evidential status of such intuitions vis a vis the real, intrinsic value of virtue and desert is hostage to (...) alternative explanations. If there is a plausible competing explanation for these intuitions, then the (putative) fact that desert and virtue are intrinsic (rather than instrumental or derivative) goods seems a much less obvious choice for the best explanation. As it turns out, there are plausible evolutionary explanations for these intuitions about desert and virtue. These evolutionary explanations suggest that it is adaptive to value desert and virtue separately from their instrumentality for other goods. Consequently, these explanations debunk intuitions about the intrinsic value of desert and virtue. (shrink)

Despite recent controversies surrounding the principle that knowledge entails truth (KT), this paper aims to prove that the principle is true. It offers a proof of (KT) in the following sense. It advances a deductively valid argument for (KT), whose premises are, by most lights, obviously true. Moreover, each premise is buttressed by at least two supporting arguments. And finally, all premises and supporting arguments can be rationally accepted by people who don’t already accept (KT).

Newton’s impact on Enlightenment natural philosophy has been studied at great length, in its experimental, methodological and ideological ramifications. One aspect that has received fairly little attention is the role Newtonian “analogies” played in the formulation of new conceptual schemes in physiology, medicine, and life science as a whole. So-called ‘medical Newtonians’ like Pitcairne and Keill have been studied; but they were engaged in a more literal project of directly transposing, or seeking to transpose, Newtonian laws into quantitative models of (...) the body. I am interested here in something different: neither the metaphysical reading of Newton, nor direct empirical transpositions, but rather, a more heuristic, empiricist construction of Newtonian analogies. Figures such as Haller, Barthez, and Blumenbach constructed analogies between the method of celestial mechanics and the method of physiology. In celestial mechanics, they held, an unknown entity such as gravity is posited and used to mathematically link sets of determinate physical phenomena (e.g., the phases of the moon and tides). This process allows one to remain agnostic about the ontological status of the unknown entity, as long as the two linked sets of phenomena are represented adequately. Haller et. al. held that the Newtonian physician and physiologist can similarly posit an unknown called ‘life’ and use it to link various other phenomena, from digestion to sensation and the functioning of the glands. These phenomena consequently appear as interconnected, goal-oriented processes which do not exist either in an inanimate mechanism or in a corpse. In keeping with the empiricist roots of the analogy, however, no ontological claims are made about the nature of this vital principle, and no attempts are made to directly causally connect such a principle and observable phenomena. The role of the “Newtonian analogy” thus brings together diverse schools of thought, and cuts across a surprising variety of programs, models and practices in natural philosophy. (shrink)

This pаpеr invеstigаtеs thе lеss discеrniblе cоst оf rаinfаll shоcks tо birth wеight оutcоmеs within thе cоntеxt оf Viеtnаm. Еxplоiting thе vаriаtiоn аcrоss districts аnd cоncеptiоn mоnths-yеаrs, wе shоw thаt in-utеrо еxpоsurе tо еxcеssivе аnd dеficiеnt rаinfаll shоcks in thе sеcоnd trimеstеr оf prеgnаncy rеducеs child’s wеight аt birth by 3.5 аnd 3.1%, rеspеctivеly. Bеsidеs, infаnts bоrn tо pооr, rurаl, аnd lоw еducаtеd mоthеrs аrе еspеciаlly vulnеrаblе tо thе аdvеrsе rеpеrcussiоns оf rаinfаll shоcks. Sincе pооr infаnt hеаlth cаn lеаvе pеrsistеnt (...) еffеcts оvеr thе lifе cyclе, thе study cаlls fоr mоrе еffоrts in intеrvеntiоn mеаsurеs tо mitigаtе thе impаcts оf rаinfаll shоcks. Additiоnаl аttеntiоn shоuld bе givеn tо childrеn аnd wоmеn frоm disаdvаntаgеd bаckgrоunds аs this grоup is thе mоst vulnеrаblе. (shrink)

Bu çalışma, geleneksel din felsefesindeki kötülük probleminin gerçek değil sözde bir problem olduğunu, dolayısıyla çözümlemeye çalışmak yerine tasfiye edilmesi gerektiğini öne süren bazı yeni tarihli iddiaları değerlendirmektedir. Öncelikle ele alınan konu sözde problem dendiğinde ne kastedildiğidir. Bir problemin iki tarafının karşılıklı olarak aynı yanlış varsayımı yaptığı durumlar literatürde sözde problem olarak nitelendirilmektedir. Makalede bu anlamda sözde problemin türleri ve ölçütleri belirlenmektedir. Arkasından geleneksel kötülük problemini oluşturan argüman ortaya koyulmakta ve problem için getirilen çözüm önerileri tanıtılmaktadır. Makalenin son bölümünde, önceki bölümlerde (...) tanıtıldığı şekliyle kötülük probleminin, önceki bölümlerde tanıtıldığı şekliyle sözde problem ölçütlerini karşılayıp karşılamadığı incelenmektedir. Varılan sonuç, kötülük problemine yönelik sözde problem iddialarının savunulabilir olmadığı, problemi tasfiye etmek için ortada sağlam bir gerekçe bulunmadığıdır. (shrink)

We examine some of Connes’ criticisms of Robinson’s infinitesimals starting in 1995. Connes sought to exploit the Solovay model S as ammunition against non-standard analysis, but the model tends to boomerang, undercutting Connes’ own earlier work in functional analysis. Connes described the hyperreals as both a “virtual theory” and a “chimera”, yet acknowledged that his argument relies on the transfer principle. We analyze Connes’ “dart-throwing” thought experiment, but reach an opposite conclusion. In S , all definable sets of reals are (...) Lebesgue measurable, suggesting that Connes views a theory as being “virtual” if it is not definable in a suitable model of ZFC. If so, Connes’ claim that a theory of the hyperreals is “virtual” is refuted by the existence of a definable model of the hyperreal field due to Kanovei and Shelah. Free ultrafilters aren’t definable, yet Connes exploited such ultrafilters both in his own earlier work on the classification of factors in the 1970s and 80s, and in Noncommutative Geometry, raising the question whether the latter may not be vulnerable to Connes’ criticism of virtuality. We analyze the philosophical underpinnings of Connes’ argument based on Gödel’s incompleteness theorem, and detect an apparent circularity in Connes’ logic. We document the reliance on non-constructive foundational material, and specifically on the Dixmier trace −∫ (featured on the front cover of Connes’ magnum opus) and the Hahn–Banach theorem, in Connes’ own framework. We also note an inaccuracy in Machover’s critique of infinitesimal-based pedagogy. (shrink)

Learning programming is thought to be troublesome. One doable reason why students don’t do well in programming is expounded to the very fact that traditional way of learning within the lecture hall adds more stress on students in understanding the Material rather than applying the Material to a true application. For a few students, this teaching model might not catch their interest. As a result, they'll not offer their best effort to grasp the Material given. Seeing however the information is (...) applied to real issues will increase student interest in learning. As a consequence, this may increase their effort to be taught. In the current paper, we try to help students learn C# programming language using Intelligent Tutoring System. This ITS was developed using ITSB authoring tool to be able to help the student learn programming efficiently and make the learning procedure very pleasing. A knowledge base using ITSB authoring tool style was used to represent the student's work and to give customized feedback and support to students. (shrink)

Thе еxprоpriаtiоn оf аgriculturаl lаnd tо prоvidе nеw lаnd fоr industriаl аnd urbаn еxpаnsiоn, rеfеrrеd tо аs cоmpulsоry аcquisitiоn, is prеvаlеnt in dеvеlоping cоuntriеs. Using Viеtnаm аs а lаbоrаtоry, this study еvаluаtеs thе impаcts оf lоsing fаrmlаnd thrоugh cоmpulsоry аcquisitiоn оn hоusеhоld wеlfаrе аnd rеаchеs thе fоllоwing findings. A 10 pеrcеntаgе pоint incrеаsе in thе prоpоrtiоn оf lаnd еxprоpriаtеd rеsults in а 2.2% dеcrеаsе in hоusеhоld wеlfаrе prоxiеd by fооd еxpеnditurе. Bеsidеs, pоliticаlly uncоnnеctеd аnd еthnic minоrity hоusеhоlds аrе disprоpоrtiоnаtеly vulnеrаblе. (...) Thе аdvеrsе wеlfаrе еffеct cоuld tаkе up tо 10 yеаrs tо еvаpоrаtе. Thе rеductiоn in hоusеhоld wеlfаrе is аttributаblе tо thе dеclinе in аgriculturаl incоmе аnd thе inаbility tо pаrticipаtе in thе nоn-аgriculturаl lаbоr mаrkеt. Othеr аspеcts оf hоusеhоld bеhаviоr fоllоwing cоmpulsоry аcquisitiоn аrе аlsо еxplоrеd, such аs sаving, sоciаl cаpitаl, lаbоr, аnd cаpitаl аllоcаtiоn. (shrink)

This chapter corrects for Susan Sontag's undeserved neglect by contemporary ethical philosophers by bringing awareness to some of the unique metaethical insights born of her reflections on photographic representations of evil. I argue that Sontag's thought provides fertile ground for thinking about: (1) moral perception and its relation to moral knowledge; and (2) the epistemic and moral value of our emotional responses to the misery and suffering of others. I show that, contrary to standard moral perception theory (e.g. Blum 1994), (...) Sontag holds that we can have general moral perceptual knowledge. I then explore Sontag's idea that certain emotional responses, like sympathy and compassion, can sometimes be impertinent, in virtue of their having false or illusory content. I explain why this is so, and show the epistemic and motivational problems it poses for moral sentimentalism. (shrink)

On one way of talking about a traditional metaethical topic, realists accept that some items appear on the list of what exists in the moral or more broadly normative domain of inquiry. They then divide over whether those items are like what science and experience suggest that all other items on the list of what exists across all domains are like – naturalistic and secular. Reductive naturalists answer this further question affirmatively. Why don’t nonnaturalists? I explore the answer that it’s (...) because normative entities are “just too different” in the sense that they are countably different things. However, I argue that this answer rests on the subtle presupposition that the normative domain doesn’t also contain uncountable entities of the sort that analytic metaphysicians call “stuff”. Taking intuitions of difference seriously points the way to a novel form of metaethical reductive naturalism. The key is to identify the stuff that matters. (shrink)

As a senior physicist colleague and our friend, Robert N. Boyd, wrote in a journal (JCFA, Vol. 1,. 2, 2022), Our universe is but one page in a large book [4]. For example, things and Beings can travel between Universes, intentionally or unintentionally. In this short remark, we revisit and offer short remark to Neil’s ideas and trying to connect them with geometrization of musical chords as presented by D. Tymoczko and others, then to Escher staircase and then to Jacob’s (...) ladder which seems to point to possibility to interpret Jacob’s vision as described in the ancient book of Genesis as inter dimensional or heavenly staircase, e.g. an inter dimensional bridge between heaven and earth (see also classic book: Hofstadter, Godel, Escher, Bach). Jacob’s vision of angels going down to earth from that staircase has been depicted for instance in William Blake art etc. In our communication with others via physics literature and discussions etc, we came to several conclusions as follows: Firstly, possibility of quantum wormhole effect to mirror particle universe, which sometimes it is termed non-orientable wormhole. While such mirror particles effect have been more than 50 years predicted with the so-called parity violation (cf. Lee & Yang, 1950s), and that is called symmetry breaking. Secondly, a series of extended experiments on laser irradiated cold water may suggest possible transition from a phase of water to be at least partially fourth phase of water, which may be composed of crystalline water (see e.g. Gerald Pollack, and also Harold Aspden on liquid crystalline). If we can imagine laser cooling effect can be done in protracted time, then we can achieve a physical representation of Aspden’s liquid crystalline. Therefore, in subsequent article (Part II) we outlined simple model of such an effect of tunneling via quantum liquid crystalline Universe, which may likely be modeled with iced-water. It is interesting to remark here that certain experiments by Stockholm University scientists have shown that X-ray triggered water can exhibit properties just like liquid crystal (cf. PRL, 2020). That is why we consider it possible that there can be quantum phase transition where liquid water (comprised of iced cubes and water) can exhibit effects such as tunneling in quantum liquid crystalline Universe. Last but not least, we admit that what we outlined here is just an initial phase; and if you wish, perhaps we can call such experiments as “wormhole-at-lab” experiments (abbreviated: WHALE). (shrink)